ea0028p203 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012
Mitic Tijana
, Floris Ilaria
, Meloni Marco
, Madeddu Paolo
, Emanueli Costanza
Endothelial cells (ECs) may display distorted epigenetic features in diabetes mellitus (DM) but this has not been investigated under combined conditions of diabetes and limb ischemia. Initial screening for histone H3 and H4 trimethylation (me3) and panacetylation of lysine residues (causing transcriptional repression and activation) were conducted using two models of hyperglycemia and ischemia. Human umbilical vein ECs (HUVECs) were cultured in EGM2 or EBM2 media (low growth f...